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Acknowledgements We are grateful to the National Natural Science Foundation of China (21276112 and 21506073), a Grant from Science and Technology Commission of Shanghai Municipality (15JC1400403), the Natural Science Foundation of Jiangsu Province (BK20150003), the Fundamental Research Funds for the Central Universities (JUSRP51409B), the Program of Introducing Talents of Discipline to Universities (111-2-06), and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions for the financial support of this research

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NAD+ is crucial as a coenzyme in reactions that generate ATP (energy) in cells, and it also serves as a substrate for enzymes involved in DNA repair and gene regulation

There is an active interaction between the fibroblast and the ECM