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(1) Specifically, the modifications involve replacements at: At position 2, alanine is replaced with D-alanine, which may make the peptide less susceptible to common proteolytic enzymes

However, when IGFBP-1 levels are chronically lowered during prolonged intra-portal hyperinsulinemia (e.g., obesity, Cushings syndrome and glucocorticoid therapy), the accelerator effect of IGFBP-1 is at play to increase serum free IGF-I (35, 40)

Wedzicha et al., 2016)

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Zhao CQ, Liu D, Li H, Jiang LS, Dai LY

Older adults, people with digestive issues, and vegans are at a higher risk of developing a Vitamin B-12 deficiency