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In both circulation and local tissues, 90% of IGF1 binds to IGFBP3 to inhibit its binding to IGF1R, thereby prolonging the half-life of the IGF1 (Tannenbaum et al., 1983)

methamphetamine) [70,152,153], dopamine receptor agonization (apomorphine) [70], dopamine receptor supersensitivity (haloperidol) [152] and reverse tolerance (amphetamine) [153]
