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Although the exact mechanism of AUD is still unclear [3], environmental factors, such as patterns of alcohol consumption, family history, and early life stressors, play a significant role in the development and the severity of AD [3,13,83]

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( F ) Quantitative real-time PCR (qRT-PCR) analysis for HILPDA and PLIN2 in HIF-2 +/+ ( n = 6) and Vil-ER T2 HIF2 LSL/LSL mice ( n = 6)

Notable are the salt bridges formed between the carboxy terminus of GSH and the side chains of VP1 R216 (protomer B) and VP1 R229 (protomer A), which form the core of a strong positive patch within the I site (Figs