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Diabetic cardiomyopathy (DCM) is one of the crucial causes leading to heart failure and adverse outcomes in patients with diabetes mellitus

Vitamin C is also necessary for the production of collagen (a structural protein in connective tissue) and is therefore important for skin, bone, and joint health

GSH-Px is one of the main enzymes that catalyze the oxidation of reduced glutathione (GSH) in the glutathione redox cycle

The levels of glutathione decrease naturally with age, as well as with certain stressors, including exercise, smoking, and pollution

Furthermore, using a Flag-AS3MT immunoprecipitation coupled to MS/MS, we identify both C33 and C62 as acceptors of the methyl group in vivo

The peptide's exceptional selectivity for senescent cells, combined with its well-characterized mechanism of FOXO4-p53 interaction disruption, provides researchers with powerful capabilities for investigating senescence biology that were previously impossible to study