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The mechanism involves the sudden spike in growth hormone affecting various systems simultaneously

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4e, PCA analysis indicated that principal component 1 (PC1) covered most of the variation in gene expression (58% of total variance), likely including the effect caused by Gclc deletion

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p21's ability to induce ROS and permanent growth arrest is independent of its PCNAbinding function An important difference between the p21 and p16 families of CDK inhibitors is the ability of the first group to bind to PCNA