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10.1210/endo-121-6-1924

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Megaloblastic anemia, which is characterized by an abundance of abnormally large and dysfunctional red blood cells, is most commonly caused by folate and/or B12 deficiency

Pro-inflammatory mediators Pro-inflammatory Mediators Obesity-induced inflammation in AT involves macrophage infiltration and stress pathway activation, with NF-B driving production of cytokines (TNF-, IL-6, IL-1) that disrupt insulin signaling (67, 68)