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There are four thiol-containing amino acidscysteine, methionine, homocysteine, and taurinebut cysteine and methionine are the major thiol-containing amino acids involved in cellular metabolism in mammals [3]

Sulfate can then either be excreted in the urine or activated to 3-phosphoadenosine-5-phosphosulfate, which, in turn, serves as a sulfate donor for sulfate ester formation

It also provides a window into mitochondrial function, neurotransmitter metabolism, and oxidative stress

doi: 10.1093/bioinformatics/btr381 [DOI] [PMC free article] [PubMed] [Google Scholar] 31

Deaths from SUD are increasing, rising from approximately 284,000 deaths in 2007 to 352,000 in 2017, creating a global health threat (6)