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C, D, and B complexes), minerals such as magnesium, natural products such as curcumin and resveratrol, important cellular detoxifier and radical scavengers such as glutathione (GSH),4 and even fatty acids such as omega-3 DHA

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The most common side effects include coloration of urine (to a red-brownish color), nausea, abdominal pain, vomiting, and hepatic fibrosis (Brittenham et al., 2003

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217 The use of a specific cell line to quantify the activation of the redox-sensitive transcription factor, nuclear factor (erythroid-derived 2)-like 2 (Nrf2), allowed to demonstrate that methotrexate also reduces the activation of the Nrf2-dependent intracellular redox signalling pathway

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