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Yang et al., 2015

However, there have been indications that regular doses of 1 g over extended periods, such as months or years, may reduce bactericidal activity in leukocytes and increase the risk of stone formation caused by temporary urate excretion elevation

These cytokines act directly on skeletal muscle cells and activate multiple signaling pathways within the cell, further promoting protein degradation via the proteasome pathway and a calcium-dependent pathway [10, 11, 14]
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This could lead to a change in the conventional risk factors for CVD and modulation therapies directly targeted at the intestinal microbiota
