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In a previous randomised, placebo-controlled trial, de Jager et al (2010) added metformin 850 mg three times daily to insulin therapy (a higher metformin dose than is usually now used) and demonstrated a number needed to harm of just under 14 for development of B12 deficiency over the 4.3 years of the trial
Most people who take B12 supplements for metabolism or weight loss never get their levels tested first
It is made by specialized cells called trophoblast cells, which later develop into the placenta
Progress in Neurobiology 88 (3): 203220
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