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57 A high toxicity line also exists parallel to the probable toxicity line, and this begins at 300 g/mL at 4 hours, equating to a 90% incidence of severe hepatotoxicity and 24% mortality

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Importantly, in conditions of low intracellular glucose where the activity of the hexose monophosphate is compromised, ketones can provide an alternative route to maintain cytosolic reducing potential [58, 60] as set by the ratio of NADP + /NADPH

231, 272, 273, 274, 275, 276, 277 It should be noted that these functional/empirical approaches are not exempted from validation

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