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Polyphenols face significant bioavailability bottlenecks when administered orally, and their pharmacokinetic properties make it difficult to reach therapeutic window concentrations in inner ear hair cells and auditory nerves (Osakabe et al., 2023), a limitation that significantly restricts their potential application in the prevention and treatment of CIO.However, reactive oxygen species present a dual role in the pathological process of CIO: as a key pathogenic factor mediating cisplatin ototoxicity and as a pharmacological basis for its tumor cell-killing effects, and this paradoxical property makes the construction of an inner-ear-targeted delivery system a central challenge for synergistic chemotherapy with polyphenolic compounds

R.HorsagerJ.BorghammerP

Principles of ex ovo competitive exclusion and in ovo administration of Lactobacillus reuteri

albicans employ strategies to tackle the complement system by secretion of several proteins

Precise Dosing: Researchers can measure exact micrograms, ensuring consistent results

Health Qual