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Control of mammalian circadian rhythm by CKI-regulated proteasome-mediated PER2 degradation

Step-by-step dose drawing 1

Female Sprague-Dawley (SD) rats (45 weeks) were supplied by the Shanghai Experimental Animal Center and housed in a specific pathogen-free environment

Though lacking enough evidence to expose the holistic alterations in the TCA cycle, the damage of mitochondria and the TCA cycle couldnt be overlooked for its essentiality in TC metabolic reprogramming

Bertin, L