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These tumours are associated with very poor survival and due to the early age of onset, treatment is linked to serious toxicities
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The underlying mechanisms of the actions of sulforaphane on cytochrome P450 expression is unclear, but may relate in part to cross-talk between the Nrf2 and Aryl hydrocarbon receptor (Ahr) pathways 26
The plasmid constructs were transformed into BL21 Star (DE3) cells (Thermo Fisher Scientific)
