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In this signaling pathway, phosphatidylinositol 3-kinase (PI3K) is the key initiating molecule, which, once activated, converts phosphatidylinositol 4,5-bisphosphate (PIP2) on the cell membrane into phosphatidylinositol 3,4,5-trisphosphate (PIP3), thereby transmitting growth and survival signals within the cell, mainly including the activation of AKT, a serine/threonine kinase

For measure specification details on the updated measure, we refer readers to the Hip and Knee Arthroplasty Complication (ZIP) folder on the CMS.gov Measure Methodology website at:

doi: 10.1126/sciadv.adh2726

Epub 2000/12/09