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Inhibition by uric acid of free radicals that damage biological molecules

Subsequent SAR studies have identified analogs 3840 (Figure 13)

The V-ATPase hydrolyzes ATP to pump protons into the vesicle lumen, generating a proton electrochemical gradient that drives glutamate accumulation within the vesicles, achieving high intra-vesicular concentrations [39]

In addition to its role in oxidizing macromolecules such as proteins and lipids, H 2 O 2 has also been proposed to function as a signal to induce the expression of genes involved in the senescence process ( Arabidopsis could be induced by ozone (Miller et al., 1999) and the expression of many other SAGs were also induced by ROS (Navabpour et al., 2003), indicating that ROS might function as a signal to promote senescence

[DOI] [PMC free article] [PubMed] 194.Liu H, Wang J, He T, Becker S, Zhang G, Li D, et al
