glutathione transferase chemical structure of P1-1 (GSTP1-1). GSTP1-1 (also Glutathione | C10H17N3O6S | CID
Description
An Orbitrap-Velos mass spectrometer was used in the negative mode, with HCD fragmentation MS 2 energy of 50 unit
10.1038/s41598-022-16372-3 53 LlabaniE.HicklinR

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This study represented a turning point
Lactate dehydrogenase A (LDHA), crucial in lactate metabolism by regulating the lactate/pyruvate interconversion, is essential both for lactate-driven TCA cycling and for histone lactylation (85)

Collectively, these findings suggest that disease-associated mutations, though mechanistically diverse, converge in their impact on astrocytic reactivity by resetting the threshold at which astrocytes enter reactive states
