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Cis-DDPs well-known nephrotoxicity, indeed, has been proved to be related to his GSH-conjugated compounds that, being metabolized to cysteine S-conjugate by cysteine S-conjugate -lyase activity (highly expressed in renal cells), is mainly responsible for proximal tubule cell damage [114]

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[DOI] [PubMed] [Google Scholar] 32.Moraes LB, Murakami AH, Fontes B, Poggetti RS, van Rooijen N, Younes RN, Heimbecker AM, Birolini D