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Although efficient, these approaches provide limited local delivery and substantial systemic exposure, restricting their clinical applicability

Saunders NR, Liddelow SA, Dziegielewska KM (2012) Barrier mechanisms in the developing brain

"c-Met: structure, functions and potential for therapeutic inhibition"

(2013) Ten misconceptions about antioxidants

Aside from that, the association between chronic inflammation and oxidative stress facilitates the release of pro-inflammatory cytokines, the stimulation of astrocyte activity, as well as the dysregulation of dopaminergic and glutamatergic pathways, which ultimately gives rise to the onset of schizophrenic symptoms ( Figure 3 ) (30)

doi: 10.1016/s0022-2143(97)90062-7 45 NiiharaY.ZerezC
