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Anti-Aging & Longevity Studies Research reveals activation of sirtuin 1 pathways through preserved NAD+ levels, triggering longevity-associated genetic programs including enhanced DNA repair, improved mitochondrial function, and reduced inflammatory responses

10.1096/fj.14-250050 FASEB J

Zhang Y, Wei W, Lv P, Wang L, Ma G
Heart Lung 58 , 6973 (2023)

In this process, activated immune cells (such as mast cells) release substances like tryptase, which specifically degrade epithelial junction proteins (e.g., E-cadherin, zonula occludens-1)

Therefore, exogenous expression in aged astrocytes of a cytoplasmically targeted PC gene could possibly decrease cellular senescence and inflammation from the senescence-associated secretory phenotype (SASP) to delay brain aging
