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KEGG enrichment analysis of enriched metabolic pathways indicated that significantly increased genes in the P3O-treated skin are enriched in the GSH metabolism pathway (Fig

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Assuming a sequential reaction, where the enzyme, GPX, must bind to both substrates, ROS and GSH, for the reaction producing GSSG to occur and letting ROS and GSH to be the leading and following substrates, respectively, is the the reaction rate for GSSG

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Although the altered redox balance in cancer contributes to tumor progression, it simultaneously presents a significant therapeutic target