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Anabolic agents are prohibited

Although FOXO4s specific effects on mitochondria are as direct as the other peptides above, it is known to regulate the expression of genes involved in oxidative stress response and energy metabolism, which can impact mitochondrial function indirectly (Liu, 2019)

Within the class S4 of hormone and metabolic modulators of the WADA Prohibited List, 39% of the adverse analytical findings (AAF) reported in 2020 resulted from SERMs (tamoxifen and clomiphene) and another 29% from AIs (letrozole, anastrozole, exemestane, and adrostatrienedione) (World Anti-Doping Agency, 2022)

Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimers disease-relevant murine model

Cagrilintide vs AOD 9604 Mechanism: Cagrilintide: Amylin receptor agonist (appetite/satiety) AOD 9604: HGH fragment (fat metabolism) Completely different Weight loss: Cagrilintide: 10-12% body weight AOD 9604: 5-8% body weight (less robust data) Cagrilintide superior Clinical evidence: Cagrilintide: Extensive Phase 2/3 trials AOD 9604: Limited clinical data Cagrilintide better studied Side effects: Cagrilintide: GI effects common AOD 9604: Minimal side effects AOD 9604 better tolerated Combination potential: Could theoretically combine (different mechanisms) No clinical data on combination Cagrilintide + semaglutide better established Verdict: Cagrilintide more powerful, better evidence