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Studies using partially purified canine and bovine NKA (Wood et al., 1977

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Direct injection of EP4 agonist CP-734432 to ovariectomized rats was also sufficient to decrease BMAd number and size while promoting de novo bone formation at both rBMAd- and cBMAd-containing sites (6)

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Sarcoplasmic reticulum Ca 2+ release and uptake Sarcoplasmic reticulum (SR) Ca 2+ release and uptake mechanisms facilitate the majority of systolic intracellular Ca 2+ increases and diastolic decreases in the mammalian myocardium, respectively ( 2+ release channel is the cardiac ryanodine receptor (RyR2), while Ca 2+ is re-sequestered by the action of the SR Ca 2+ -ATPase (SERCA2a) ( Recent work by 2+ leak, resulting in reductions in the SR Ca 2+ content and cytosolic Ca 2+ transients

11,16,18 Nonpharmacologic treatment similar to that of guaifenesin can be recommended