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Acknowledgements The authors acknowledge NIH grants F30DK103511 (M.A.O.), T32HD007009 (M.A.O.), R01DK61931 (J.R.T.) and R01DK68271 (J.R.T.)

2.3.3 Ferroptosisis and inflammation Unlike immunologically silent apoptosis, ferroptosis is immunogenic, as cells undergoing ferroptosis release cell contents including DAMPs and alarm proteins due to plasma membrane rupture, amplifying cell death and triggering a cascade of inflammation-related responses ( 3 Ferroptosis inducers and inhibitors Ferroptosis inducers and inhibitors act by modulating key mechanisms in the ferroptosis pathway mentioned above to respectively promote or inhibit iron-dependent cell death ( 3.1 Ferroptosis inducers Erastin, first reported in 2003 ( 3.2 Ras selective lethal compound 3 Ras-selective lethal small molecule 3 (RSL3) was first reported in 2008 ( 3.3 The inhibitor of ferroptosis inhibitor 1 Bersuker et al

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Severe vitamin B12 deficiency can lead to memory loss, joint pain, and vision problems, among other complications