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The study found that NNMT inhibitors "reduced intracellular 1-MNA, increased intracellular NAD+ and S-(5-adenosyl)-L-methionine (SAM), and suppressed lipogenesis." This metabolic improvement occurs within days of starting treatment, before any weight loss becomes measurable

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PubMed, Laisk, Triin, et al

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J.Ayalon-DangurI.Ayalon-DangurR.NaamanyE.Gafter-GviliA.KorenG.et al (2019)

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