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A biomarker is considered to enable the detection of a pathological condition or its severity and ideally, should have the capacity to be detected in the pre-disease state or during the diseased state

Inhibition of reactive oxygen species by Lovastatin downregulates vascular endothelial growth factor expression and ameliorates blood-retinal barrier breakdown in db/db mice: Role of NADPH oxidase 4

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Additionally, exposure to toxins, heavy metals, and oxidative stress can disrupt enzymatic activity within the cycle, affecting its overall function and metabolic stability