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Nature 288, 715717 (1980)

Simultaneously, the GHK-Cu complex has been shown in vitro to interact with components of the TGF- superfamily signaling axis and to up-regulate expression of anti-apoptotic and extracellular matrix (ECM) remodeling genes, including those encoding fibronectin, collagen I, and various matrix metalloproteinases (MMPs) as well as their inhibitors (TIMPs)

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