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in contrast, the cytotoxicity of the PtII drugs, cisplatin and carboplatin, was only significantly increased in one of the two relatively resistant lines (SKOV-3) and in the sensitive (CH1) line after GSH depletion

Moreover, common chemotherapies and targeted drugs may have cross (overlapping) resistance mechanisms

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Glutathione is a naturally occurring antioxidant produced by the liver and nerve cells in the central nervous system

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