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In an attempt to improve response rates, combination regimens that incorporate both targeted agents and immunotherapies are currently undergoing clinical evaluation in a wide range of cancers [210]

After all, this is the solution evolution came up with

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That is, quinolinic acid may have toxic effects on the CNS, contribute to oxidative stress and neuroinflammation in both dopaminergic and glutaminergic neurons (198)

doi: 10.1007/bf00755687
"DIABASI trial." J Endocr Soc 2018
