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Among the antibiotics that were shown to have strong anti-mycoplasma properties are different inhibitors ofprotein synthesis mainly tetracyclines or macrolides as well as quinolones [111]

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Metabolic demands are high during wake to support different body movements, food seeking, reproduction as well as survival of the organism from predators (Ding et al., 2018

The term immunosuppressive polynucleotide as used herein, represents an immunomodulating polynucleotide capable of antagonizing an immune response, as determined by e.g., a reduction in the activation or lack of activation of NFB or lack of increase in the levels of cell surface marker(s) of activation of function or a reduction or lack of increase in the secretion of at least one inflammatory cytokine or at least one type I interferon in an immune cell (e.g., antigen-presenting cell) to which an immunosuppressive polynucleotide was delivered (e.g., in comparison to another immune cell (e.g., antigen-presenting cell) to which an immunosuppressive polynucleotide was not delivered) or in an immune cell that interacts with an immune cell (e.g., antigen-presenting cell) to which an immunomodulating polynucleotide was delivered (including direct cell-to-cell interactions as well as indirect stimulation, e.g., from one or more cytokines secreted by the cell to which an immunomodulating polynucleotide was delivered)

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