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The amount of G6pD enzyme deficiency varies, depending on the mutation in the gene

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94 Characterized by downregulated pro-apoptotic proteins (eg, Bax) and upregulated anti-apoptotic proteins (eg, Bcl-2) under hypoxia, this phenomenon reduces the Bax/Bcl-2 ratio, stabilizes mitochondrial membrane potential, and suppresses mPTP opening, apoptosome formation, and Caspase-3 activation

Clinical trials of Bapineuzumab are mixed, with some Bapineuzumab studies suggesting mild cognition improvements and others suggesting little efficacy in slowing disease progression

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The proposed DC Function measure would also follow a calculation approach similar to the existing functional outcome measures, which are CBE endorsed, with some modifications