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Yamamoto S, Matsushita Y, Nakagawa T et al (2014) Circulating adiponectin levels and risk of type 2 diabetes in the Japanese

Meiosis I results in the formation of two haploid cells: a smaller first polar body (PB1) and a larger secondary oocyte

EMBO J 39:e103365 Tsuchiya H, Ohtake F, Arai N, Kaiho A, Yasuda S, Tanaka K, Saeki Y (2017) In vivo ubiquitin linkage-type analysis reveals that the Cdc48-Rad23/Dsk2 axis contributes to K48-linked chain specificity of the proteasome

They are synthesised in excess during untreated (or inadequately treated) type 1 diabetes mellitus

Likewise, direct depletion of cystine from plasma using an engineered cystine-degrading enzyme conjugate ( i.e., cyst(e)inase) arrests tumor growth and triggers cell death (Cramer et al., 2017)