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Sleep problems may be unrelated to B12 and require separate evaluation

MEPSEVII (vestronidase alfa-vjbk) dosing chart Recommended Infusion Rate Schedule by Patient Weight for Administration of MEPSEVII at Recommended Dose of 4 mg/kg MEPSEVII (vestronidase alfa-vjbk) dosing chart Recommended Infusion Rate Schedule by Patient Weight for Administration of MEPSEVII at Recommended Dose of 4 mg/kg Calculating the Dose Weigh the patient to determine the number of vials to be diluted based on the patients weight and the recommended dose of 4 mg/kg Total dose (mg) = Patients weight (kg) x 4 mg/kg (recommended dose) Total number of vials = Total dose (mg) divided by 10 mg/vial Round to the next whole vial to determine the final total volume and number of vials needed based on the patients weight Volume (mL) of calculated dose = Total dose (mg) divided by the 2 mg/mL concentration Calculating the Dose Weigh the patient to determine the number of vials to be diluted based on the patients weight and the recommended dose of 4 mg/kg Total dose (mg) = Patients weight (kg) x 4 mg/kg (recommended dose) Total number of vials = Total dose (mg) divided by 10 mg/vial Round to the next whole vial to determine the final total volume and number of vials needed based on the patients weight Volume (mL) of calculated dose = Total dose (mg) divided by the 2 mg/mL concentration

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Vessel formation is induced prior to the appearance of cartilage in BMP-2-mediated heterotopic ossification