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S.BarbisanF.AzzolinV

In a recent trial, a significant reduction in advanced cancers was observed in patients randomized to vitamin D supplementation (67)

The Sept4 septin locus is required for sperm terminal differentiation in mice

Glutathione oxidation is associated with altered microtubule function and disrupted fertilization in mature hamster oocytes

Nature 615 , 668677 (2023)

4,5 Recent studies indicate that this reduction is not due to cell death, but rather to -cell identity loss 6,7,8,9,10 a process in which cells lose their mature phenotype, dedifferentiate into progenitor-like cells, or transdifferentiate into other pancreatic endocrine cells under chronic diabetic stress or owing to genetic defects