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These compounds have long been demonstrated to be the main excretion form of Cd [19] and Hg [20,21] in mammals and their toxicity is modulated by the nature of the metal-binding biothiol [22,23,24]

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Biochem Pharmacol 1998

Unlike sporadic CRC, which often occurs in the distal colon and rectum, LS-associated CRCs predominantly arise in the proximal (right-sided) colon, particularly in the cecum and ascending colon (45)

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