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This activates protein kinase A (PKA), which phosphorylates and stabilizes MITF (microphthalmia-associated transcription factor), driving transcriptional upregulation of tyrosinase, TRP-1, and TRP-2rate-limiting enzymes in the eumelanin biosynthesis pathway (Abdel-Malek et al., Pigment Cell Research, 2001)

Furthermore, carnitine is crucial in the regulation of the acyl-CoA/CoA balance, which in turn, modulates the carbohydrate and the lipid metabolisms

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10.1016/j.bone.2015.02.008 Bone 123 SchraderM.CostelloJ.GodinhoL