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Depression is a acotraveler with a number of other medical and psychiatric conditions and numerous medications can cause depressive symptoms
Bruce Ames: Exactly

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Rewiring lipid metabolism: The central role of CPT1 in metabolic dysfunction

The rationale for adding it to tirzepatide is that calorie restriction and GI side effects from GLP-1 medications can reduce B12 absorption, potentially leading to deficiency over time

Ann NY Acad Sci 2004;1033:168-76
