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We determined the structure of FLVCR2 in n -dodecyl-b-maltoside (DDM) detergent to 3.4 using cryo-EM (Figs 3B and S2AF, Table S1)

Potential candidate structures would be the double-stranded (ds)RNA replicative intermediate as well as highly structured RNA elements in the 5UTR, within the coding region in NS4B and NS5B 25 , as well as in the 3UTR

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The outer surface of CTL1 is mostly hydrophobic, with a groove at the back where we observe the elongated densities in the map, whereas the putative binding pocket largely consists of hydrophilic residues (Fig 4F)