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doi:10.1136/bjsm.15.4.250 38

"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study"

Kraaijenhof JM, Tromp TR, Nurmohamed NS, Reeskamp LF, Langenkamp M, Levels JHM, Boekholdt SM, Wareham NJ, Hoekstra M, Stroes ESG, et al

The question arises, can anything be done to limit this provision and/or prevent its catabolism in a way that would reduce the amount of the intended products, i.e., yielding NADPH, nucleotides, folate, hexosamines, serine, glycine, TGs, PLs, lactate, in a bid to limit cancers potential

SIRT1 flox/flox (denoted SIRT1 flox/flox mice hereafter) were used as control mice

However, these cell lines have certain limitations, which are described below: Limitations of 2D cultures: (a) genetic and epigenetic abnormalities resulting from long-term in vitro culture in such an unphysiological environment