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Xie et al., 2017)
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( a ) Co-localization of BRCA1 foci and mCherry DSB foci in U2OS-mCherry-LacI-Fok1 cells treated with the IDH1 inhibitor (IDH1i) alone or supplemented with KG, l-carnitine (l-Carn), or O-acetyl-l-carnitine (Ac-Carn) (DMSO and IDH1i, n = 26
When carnitine availability is low, sensations of muscle weakness , cramps, muscle discomfort or a feeling of heavy legs may appear, especially with physical activity

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