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Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

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Elevated intracellular GSH levels blocked bortezomib-induced nuclear factor erythroid 2-related factor 2 (NFE2L2, NRF2)-associated stress responses, including upregulation of the xCT subunit of the Xc- cystine-glutamate antiporter