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J Lipids (2011) 2011:575840

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In addition, the first pass effect of liver result in some metabolism of curcumin in the intestinal mucosa and liver, lead to reduce drug absorption (132), Only a small amount of curcumin enters the blood supply, which is much lower than the concentration required to inhibit most of the targets of curcumin, so the therapeutic effect is much lower than expected (135)