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While the exact causative mechanism isnt always clear, high dose opioid use can lead to rhabdomyolysis, which can increase the risk of acute renal failure and death

An adequate and hopefully incisive therapeutic action will therefore depend on a finely orchestrated balance between the efficacy of the single treatment for the specific pathogenetic mechanism and the control of potentially noxious interactions among the different therapies

Retatrutide is an unlicensed investigational triple incretin receptor agonist by Eli Lilly