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The effects are partly mediated by inhibiting neuroinflammation and NLRP3 inflammasome coupled to PPAR upregulations.

JAMA Otolaryngol Head Neck Surg

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Recently, less traditional transcriptional roles for AR, such as those impacting non-coding RNAs as well as transcription-independent roles that include AR-dependent splicing programs and translation control have been recognized to contribute to aggressive CaP features and treatment resistance